Results
| PMID | 21751163 |
| Gene Name | PGR |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) |
| Population size | 98 |
| Population details | 98 (54 patients with a diagnosis of endometriosis, 44 women without endometriosis) |
| Sex | Female |
| Associated genes | PROGINS |
| Other associated phenotypes |
Endometriosis |
|
Genet Mol Res. 2011 Jul 6;10(3):1364-70. doi: 10.4238/vol10-3gmr913. Costa, I R| Silva, R C P C| Frare, A B| Silva, C T X| Bordin, B M| Souza, S R| Ribeiro Junior, C L| Moura, K K V O Nucleo de Pesquisas Replicon, Pontificia Universidade Catolica de Goias, Goiania, GO, Brasil. iasmimribeirodacosta@gmail.com We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2 and A2/A2) were determined by polymerase chain reaction and analyzed on a 2% agarose gel stained with ethidium bromide. The frequency of polymorphic genotypes (A1/A2 and A2/A2) was significantly higher in patients with endometriosis (33%) than in the control group (16%). We conclude that there is a significant correlation between PROGINS polymorphism and endometriosis. Mesh Terms: Adult| Alu Elements/genetics| Brazil| Endometriosis/*genetics| Female| Genetic Predisposition to Disease| Genome-Wide Association Study| Genotype| Humans| Middle Aged| Polymorphism, Genetic| Receptors, Progesterone/blood/*genetics| Risk Factor |
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